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Accurate selection of the cognate tRNA from the cellular pool by an aaRS is known to involve a dual discrimination mechanism based upon velocity of the aminoacylation reaction and substrate binding affinity, both of which will only reach optimum levels with the cognate molecule (Yarus and Berg 1967

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Disruption of astrocyte-dependent dopamine control in the developing medial prefrontal cortex leads to excessive grooming in mice

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