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The Rule of Thumb for Medication Dosage: "Least Amount for Therapeutic Response" A good rule of thumb when taking any medication, including Tylenol, is to use the least amount that still produces the desired therapeutic response

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Pharmacol 230:167–74 [DOI] [PMC free article] [PubMed] [Google Scholar] 290.Wang XS, Ong WY, Connor JR