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There are many forms of oxidative damage to RNA: 1 ) direct RNA strand breaks (61), as a result of the production of nucleic acid bases or their peroxyl groups, with the abstraction of hydrogen atoms from adjacent ribose molecules, which in turn results in the breakage of the RNA strand, and 2 ) translation errors, caused by oxidized mRNA, that may lead to premature cessation of translation or degradation of peptide chains, resulting in short-chain polypeptides and protein changes (62)

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The extracellular matrix, the structural scaffold beneath the skin’s surface, needs to be actively rebuilt rather than left to passively contract