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Resveratrol also attenuates the acetylation, phosphorylation, and nuclear translocation of NF-κB [60] and inhibit iNOS expression in colon cancer cells (a key enzyme in colon tumorigenesis induced by pro-inflammatory and cytokines agents) and the IGF-1R/Akt/Wnt pathways, and activates p53 to hampered cell and tumor development [60]

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NNMT emerges as a novel regulator of adipose tissue function and energy expenditure