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TRT & Men's Health Clinic in Laveen, Arizona | Gameday Men's Health

doi: 10.1200/JCO.2003.05.060

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Mechanistically, α-KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-γ, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136