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These observations, together with the fact that spine head size and geometry are associated with AMPA receptor content and maturation status (Matsuzaki et al., 2001), suggest that MET signaling may control many aspects of glutamatergic synapse development, including the timing of excitatory synapse maturation (Qiu et al., 2014)

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The fatty acid acylation of cagrilintide enables albumin binding in circulation, reducing renal clearance and extending the elimination half-life to support once-weekly dosing