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In anesthetized rats, these authors show that cocaine (10 mg/kg, i.p) produced a general decrease of the firing rate and bursting of dopamine neurons, but in awake rats, however, injection of cocaine led a decrease in firing rate and bursting in only 14% of dopamine neurons, but most of the other dopaminergic neurons underwent increases in firing rate and bursting that was correlated with locomotor activity in 52% of the neurons [116] Effect of Psychostimulants on Dopamine Degradation Methamphetamine In this section, we discuss how methamphetamine and cocaine affect MAO and COMT enzymes given their importance in dopamine degradation [37, 117–121]
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