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418–420 This subtype of hepatocellular carcinoma has high-density EB-associated TIL infiltration and poorer RFS and OS characteristics, which may be related to the upregulation of CD28 co-stimulatory signals, T-cell receptors and other signaling pathways in HCC-IS, leading to CD8 + T-cell depletion and thus induced immune escape 420 in gastric cancer are silenced up to 75% EBVaGC exhibits a high frequency of DNA methylation, thus serving as a strategy for the virus to evade host immune regulation