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However, previous studies documented that NO may be also considered as a gastroprotective factor, when released from gastric epithelium in smaller amounts and that this NO contributes to the reduction of the area and number of gastric lesions induced by variety of noxious agents (7,8,10,30,34)

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NAD+ activates certain cellular receptors that cause temporary blood vessel dilation and smooth muscle relaxation, which can manifest as chest pressure, facial flushing, or a sensation of warmth spreading through the body