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Methemoglobin formation in hemoglobin vesicles and reduction by encapsulated thiols

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Research indicates that certain components in plants, such as saponins, K, and phenolic compounds, can promote diuresis, saluresis, and natriuresis either individually or in combination by (a) disrupting the reabsorption of water and electrolytes (Na + and Cl − ) in the renal tubules or (b) inhibiting Na + /K + -ATPase activity in the kidneys by directly binding to the enzyme, impairing its function, or altering membrane fluidity