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Dopamine also enhanced LPS-mediated NO production in RAW264.7 cells, although only at higher concentrations (5 × 10 −5 M) and to a much lesser extent than other catecholamines (Chi et al., 2003)

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An animal model of cystitis demonstrated that bladder pain involved ATP-dependent HMGB1 release from macrophages, causing nociceptor excitation and resulting in bladder pain [79]

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