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Additional experiments suggested that Mtb PtpA interacted with PRMT6 and promoted PRMT6’s methyltransferase activity to add H3R2me2a marks on the GPX4 promoter, resulting in suppression of GPX4 transcription and induction of ferroptosis

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FOXO4-DRI inhibits FOXO4-P53 binding and promotes P53 phosphorylation To further elucidate the specific mechanism of FOXO4-DRI in anti-aging, we induced senescence in endothelial cells under OGD conditions and treated these cells either PBS or FOXO4-DRI