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128,129 Of note, serotonin and norepinephrine reuptake inhibitors (SSRIs and SNRIs, respectively) have shown efficacy in pain management, 130 and ascorbate-deficient animals have been observed to have lower norepinephrine concentrations than controls

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Accumulation of EMSY in KEAP1-mutant tumors suppresses type I interferon responses and promotes immune evasion, a phenotype which can be reversed with the STING agonist, DMXAA [39]