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This review systematically summarizes the research progress on flavonoid compounds in SR, comprehensively elaborating on their phytochemistry, extraction methods, separation and purification techniques, in vivo metabolism, immunological and pharmacological effects, toxicity, and novel dosage forms

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Excessive iron promotes the Fenton reaction, generating more ROS, further damaging melanocytes, while glutathione peroxidase 4 (GPX4), a key regulatory factor in ferroptosis, shows significantly downregulated expression in vitiligo