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Early haematological response begins with reticulocytosis (increased production of immature red blood cells) typically by day 3-4 of treatment , particularly with injectable forms, though the full resolution of symptoms may take several weeks to months

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Similarly, pooled analyses from the STEP-HFpEF and STEP-HFpEF-DM trials demonstrated that semaglutide not only improved HF outcomes but also decreased the requirement for loop diuretics by up to 17%, compared with an increase in the placebo group