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Meanwhile, A metabolic-syndrome study reported higher energy expenditure, fatty-acid oxidation, reduced fat accumulation, and improved insulin sensitivity in mouse models

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Conflicting evidence links chronic levodopa therapy in patients with Parkinson disease to an increased risk of symptomatic vitamin B12 deficiency, perhaps because carbidopa metabolism through the catechol-O-methyl transferase pathway may deplete vitamin B12-dependent cofactors (204