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While cationic polymers like PEI can enhance loading, they introduce well-documented cytotoxicity constraints, forcing an explicit engineering trade-off between delivery potency and biological safety (Shirbaghaee and Bolhassani, 2016)

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[DOI] [PubMed] [Google Scholar] 64.Krajka-Kuźniak V., Szaefer H., Ignatowicz E., Adamska T., Baer-Dubowska W