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Furthermore, the diverse range of metabolic markers targeted in these studies—AMPK, SREBP1, SREBP2, CSF2/CENPE, HIF-1α/VEGF, Akt/mTOR, IL-6, and now Nrf2/HO-1—suggests that our current understanding of lactoferrin’s antioxidant mechanisms remains incomplete

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46, 47 Knock out (−/−) of the AT 1a receptor gene decreased baseline blood pressure 46, 48 and abolished the pressor response to Ang II infusion, 46, 49 whereas deletion of AT 1b genes did not alter baseline blood pressure, nor the pressor response to Ang II