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Most patients were females (79%), adults (92%) aged 51 years or older (66%) with pre-existing conditions (74%) such as undernutrition, alcohol-use disorder, or kidney disease, and had an ongoing infection (69%)

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This indicates a strong need for better understanding of the tumor response to the treatment to overcome treatment resistance and reduce tumor progression, as well as to identify therapeutic selectivity, increasing the treatment sensitivity of the tumor while reducing adverse effects in normal tissue [1]