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As outlined in Supplementary Table 1 , HMC3 cells have been employed to study a broad spectrum of disorders, including classical neurodegenerative diseases (AD, PD, and ALS), acute CNS injuries (ischemic stroke, SCI, and intracerebral hemorrhage), metabolic and vascular insults (hyperglycemia, DR, and angiogenesis), cancer (gliomas and brain metastases), infectious diseases (HIV, SARS-CoV-2, Treponema pallidum , and enterovirus), and environmental or chemical neurotoxicity